University of California San Francisco

Monika Sarkar, MD, MAS

Monika Sarkar MD MAS
Monika
Sarkar
MD, MAS

Associate Professor 
Department of Medicine
Division of Gastroenterology and Hepatology

Address

513 Parnassus Avenue MSB, #357F
San Francisco, CA 94143
United States

ORCID: 0000-0003-4233-1062

Biography

My clinical focus is on women with liver disease, including pregnancy-related liver conditions and reproductive health. My research program is focused on the role of sex hormones in modulating liver disease in women. I have a specific research interest in young women with the hyperandrogenic condition known as Polycystic Ovarian Syndrome given their high risk for developing Non Alcoholic Fatty Liver Disease (NAFLD) and early onset liver scarring. Within the transplant setting my focus is reproductive health, including pregnancy and contraceptive management in transplant recipients.

Education

Institution Degree Dept or School End Date
UCSF Transplant Hepatology Fellowship 2013
UCSF Gastroenterology Fellowship 2012
UCSF M.A.S. in Clinical Research Graduate Division (Advance Training in Clinical Research) 2012
University of Pennsylvania Internal Medicine Residency 2009
UCSF M.D. School of Medicine 2006
Vassar College BA 2002

Board Certifications

American Board of Internal Medicine
American Board of Internal Medicine - Gastroenterology
American Board of Internal Medicine - Transplant Hepatology

Awards & Honors

Award Conferred By Date
R03 NIDDK 2022/2024
K23 NIDDK 2017/2023
K Scholars Team Science Award UCSF 2017/2018
UCSF Hellman Research Award UCSF 2016/2018
RAP Pilot Award for Junior Investigators UCSF 2016/2017
Liver Center Flex Funds UCSF 2015/2016
Liver Center Pilot/Feasibility Research Award UCSF Liver Center 2014/2015
Sheila Sherlock Career Development Research Award AASLD 2013/2015
Advanced Hepatology Fellowship Award AASLD 2012/2013

Clinical Expertise

Alcoholic Liver Disease
Autoimmune Hepatitis
Cirrhosis
Drug-Induced Hepatitis
Fulminant Hepatic Failure
Hemochromatosis
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Liver Cancer)
Liver Transplantation
Living Donor Liver Transplantation
Nonalcoholic Fatty Liver Disease
Polycystic Liver Disease
Primary Biliary Cirrhosis
Primary Sclerosing Cholangitis

Clinical Trials

  1. Bicalutamide Therapy in Young Women With NAFLD and PCOS (NCT05979389)
    Related Conditions: Nonalcoholic Fatty Liver Disease, Polycystic Ovary Syndrome, Liver Disease| Start Date: | End Date:
  2. Spironolactone Therapy In Young Women With NASH (NCT03576755)
    Related Conditions: Nonalcoholic Steatohepatitis, Steatohepatitis, Liver Disease, Nonalcoholic Fatty Liver Disease| Start Date: | End Date:

Program Affiliations

UCSF Liver Center

Grants and Funding

  • Nonalcoholic Fatty Liver Disease (NAFLD) in Polycystic Ovary Syndrome: The Role of Androgens on Liver Injury and NAFLD Progression | NIH | 2023-09-01 - 2028-06-30 | Role: Principal Investigator
  • Influence of Androgens on Tissue-Specific Lipid Metabolites and Liver Injury in Young Women with NAFLD | NIH | 2022-02-15 - 2024-07-31 | Role: Principal Investigator
  • Influence of Androgens on Tissue-Specific Lipid Metabolites and Liver Injury in Young Women with NAFLD | NIDDK | 2022-03-15 - 2024-03-15 | Role: Principle Investigator
  • Androgens and Nonalcoholic Steatohepatitis: The Role of Male Sex Hormones in Women with NASH | NIH | 2017-07-10 - 2023-06-30 | Role: Principal Investigator

Research Narrative

My research program is focused on the role of sex hormones on liver injury in women, including the effects of reproductive aging, pregnancy, and androgens. I have a specific interest in young women with the hyperandrogenic condition known as Polycystic Ovarian Syndrome as these women are at high risk for developing Non Alcoholic Fatty Liver Disease and early onset liver scarring. Within the transplant setting I also study sex differences in waitlist and post transplant outcomes.

Research Interests

Women with chronic liver disease

Non invasive measures of liver fibrosis

Gender differences in liver transplant outcomes

 

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 10
  1. Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses.
    Jespersen JM, Avanesyan L, Publicover J, Carey ND, Patel RK, Edwards AW, Stenske S, Shin J, Li J, Simone M, Chew NW, Wong N, Trilok S, Erickson A, Rao A, Loo CP, Stec M, Anderson M, Cloherty G, Sarkar M, Nishimura SL, Combes AJ, Wakil AE, Segal MR, Fragiadakis GK, Cooper SL, Baron JL| | PubMed
  2. Institutional Strategies for Overcoming Academic Bullying, Rising Above Moral Injury, and Achieving Success.
    Paul S, Sarkar M, Rossi AP, Gordon EJ, Brennan DC, Pillai AA| | PubMed
  3. Temporal Trends in Hepatitis C Virus Screening and Management in Pregnant Women and Infants Between 2014 and 2024 in San Francisco, California.
    Betancourt M, Kaur R, Gamez J, Price J, Luetkemeyer A, Seidman D, Sarkar M| | PubMed
  4. Liver cirrhosis among females with cystic fibrosis using hormonal contraception.
    Chin J, Sarkar M, Magaret AS, Hsu C, West N, Walker P, Langfelder-Schwind E, Taylor-Cousar JL, Ladores-Barrett S, Hadijiliadis D, Roe AH, Uluer A, Mody S, Jain R, Dayton LAB, Godfrey EM| | PubMed
  5. Transplant professionals' knowledge, attitudes, and practices related to transgender and gender diverse patient care: A national survey.
    Paul S, Rossi AP, Gordon EJ, Jones J, Balliet W, Coscia L, Katz-Greenberg G, Kumar V, Lee TH, Ravirala R, Shingina A, Targownik LE, Sarkar M| | PubMed
  6. Low anti-Mullerian hormone in reproductive age is associated with MASLD in midlife.
    Cooper KM, Wellons M, Terry JG, Huddleston HG, Cedars MI, Maldonado SS, Sarkar M| | PubMed
  7. Chronic liver disease and hepatology care in transgender and gender diverse populations.
    Nguyen TN, Jackson WE, Roth NC, Cinque F, Sarkar M, Samala N, Lee RS, Strauss AT, Wisocky J, Patel K, Sebastiani G, Streed CG, Lake JE, Lee TH| | PubMed
  8. Contraceptive safety in liver disease: The cost of overstating risk.
    Garriga M, Cedars M, Whetstone S, Sarkar M| | PubMed
  9. Clinical cure of chronic hepatitis B is dependent on activation and perpetuation of robust CD4 + T cell responses.
    Jespersen J JM, Avanesyan L, Publicover J, Carey ND, Patel RK, Edwards AW, Stenske S, Shin J, Li J, Simone M, Chew NW, Wong N, Trilok S, Erickson A, Rao A, Loo CP, Stec M, Anderson M, Cloherty G, Sarkar M, Combes AJ, Wakil AE, Segal MR, Fragiadakis GK, Cooper S, Baron JL| | PubMed
  10. Reproductive health in the liver transplant recipient.
    Dukewich M, Coscia L, Afshar Y, Sarkar M| | PubMed